This recent featured work proposes an integrated experimental/computational approach for the design of shape memory devices fabricated by hot-processing with potential for use as gastroretentive drug delivery systems and for personalized therapy if 4D printing is involved. The proposed approach provided useful results and recommendations for the design of PVA-based shape memory drug delivery systems.
N. Inverardi, G. Scalet, A. Melocchi, M. Uboldi, A. Maroni, L. Zema, A. Gazzaniga, F. Auricchio, F. Briatico-Vangosa, F. Baldi, S. Pandini. Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems, Journal of the Mechanical Behavior of Biomedical Materials, 124, 104814, 2021. https://www.sciencedirect.com/science/article/pii/S1751616121004550